Pesquisa sobre: CHECKPOINT KINASE 1 
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Descritor Inglês:   Checkpoint Kinase 1 
Descritor Espanhol:   cinasa 1 reguladora del ciclo celular (checkpoint 1) 
Descritor Português:   Quinase 1 do Ponto de Checagem 
Sinônimos Inglês:   Checkpoint-1 Kinase
Chk1 Kinase
Chk1 Protein Kinase
Protein Kinase, Chk1  
Categoria:   D08.811.913.696.620.682.700.143
Definição Inglês:   A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle. 
Nota Histórica Inglês:   2017 (2004) 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número do Registro:   56510 
Identificador Único:   D000071877 

Ocorrência na BVS:
 

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